The Guidelines envisage the isolation of GH/EH from other airspace users by requiring it to climb-out and recover in segregated airspace and to fly IFR/OAT in the cruise in non-segregated airspace at high altitudes that are above those occupied by manned aviation.
EUROCONTROL Air Traffic Management Guidelines for Global Hawk in European airspace
These Guidelines establish a set of minimum ATM requirements for Global Hawk (GH) / Euro Hawk (EH) flight in European airspace, with the primary purpose of enabling GH/EH operators to use them as the basis for negotiating access to national airspace within Europe.